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CHMP5

CANCER ATLAS

Gene description

 Charged multivesicular body protein 5

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042883
HPA056437
CAB033874

GENE INFORMATION

Gene name

 CHMP5 (HGNC Symbol)

Synonyms

 C9orf83, CGI-34, HSPC177, SNF7DC2, Vps60

Description

 Charged multivesicular body protein 5 (HGNC Symbol)

Entrez gene summary

 CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 33264879 - 33282069

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086065 (version 83.38)

Entrez gene

 51510

UniProt

 Q9NZZ3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZZ3

Antibodypedia

 CHMP5 antibodies

PROTEIN BROWSER
CHMP5-001
CHMP5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHMP5-001
ENSP00000223500
ENST00000223500
Q9NZZ3 [Direct mapping]
Charged multivesicular body protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000920 [cell separation after cytokinesis]
GO:0001919 [regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0007080 [mitotic metaphase plate congression]
GO:0008333 [endosome to lysosome transport]
GO:0010008 [endosome membrane]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0046755 [viral budding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:1901673 [regulation of mitotic spindle assembly]
Show all
 219 aa
24.6 kDa 		No 0
CHMP5-201
ENSP00000442725
ENST00000419016
Q9NZZ3 [Direct mapping]
Charged multivesicular body protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0010008 [endosome membrane]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0046755 [viral budding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:1901673 [regulation of mitotic spindle assembly]
Show all
 171 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.