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AQP6

CANCER ATLAS

Gene description

 Aquaporin 6, kidney specific

Protein class

 Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA015278

GENE INFORMATION

Gene name

 AQP6 (HGNC Symbol)

Synonyms

 AQP2L

Description

 Aquaporin 6, kidney specific (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49967194 - 49977139

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086159 (version 83.38)

Entrez gene

 363

UniProt

 Q13520 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q13520

Antibodypedia

 AQP6 antibodies

PROTEIN BROWSER
AQP6-001
AQP6-004
AQP6-201
AQP6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP6-001
ENSP00000320247
ENST00000315520
Q13520 [Direct mapping]
Aquaporin-6
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005253 [anion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007588 [excretion]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030658 [transport vesicle membrane]
GO:0042476 [odontogenesis]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 282 aa
29.4 kDa 		No 6
AQP6-004
ENSP00000449830
ENST00000551733
F8VW87 [Direct mapping]
Aquaporin-6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0009992 [cellular water homeostasis]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
 108 aa
11.2 kDa 		No 1
AQP6-201
ENSP00000477688
ENST00000615425
Q13520 [Direct mapping]
Aquaporin-6
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005253 [anion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007588 [excretion]
GO:0009992 [cellular water homeostasis]
GO:0015112 [nitrate transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015706 [nitrate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030658 [transport vesicle membrane]
GO:0042476 [odontogenesis]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 282 aa
29.4 kDa 		No 6
AQP6-202
ENSP00000477759
ENST00000618286
Q9NSV5 [Direct mapping]
Aquaporin-6; Putative uncharacterized protein DKFZp434D2030
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0009992 [cellular water homeostasis]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
 163 aa
17.1 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.