Expression of EIF2AK1 in cancer - Summary

CANCER ATLAS

Gene description

Eukaryotic translation initiation factor 2-alpha kinase 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA016496	CAB022082

GENE INFORMATION
Gene name	EIF2AK1 (HGNC Symbol)
Synonyms	HRI, KIAA1369
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	7
Cytoband	p22.1
Chromosome location (bp)	6022244 - 6059230
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086232 (version 83.38)
Entrez gene	27102
UniProt	Q9BQI3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQI3
Antibodypedia	EIF2AK1 antibodies

PROTEIN BROWSER

EIF2AK1-001	EIF2AK1-004	EIF2AK1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF2AK1-001 ENSP00000199389 ENST00000199389	Q9BQI3 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 1 A0A024QZU1 [Target identity:100%; Query identity:100%] Eukaryotic translation initiation factor 2-alpha kinase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002526 [acute inflammatory response] GO:0004672 [protein kinase activity] GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0006909 [phagocytosis] GO:0006950 [response to stress] GO:0008285 [negative regulation of cell proliferation] GO:0009605 [response to external stimulus] GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation] GO:0010999 [regulation of eIF2 alpha phosphorylation by heme] GO:0020037 [heme binding] GO:0030225 [macrophage differentiation] GO:0042803 [protein homodimerization activity] GO:0045993 [negative regulation of translational initiation by iron] GO:0046501 [protoporphyrinogen IX metabolic process] GO:0046777 [protein autophosphorylation] GO:0046984 [regulation of hemoglobin biosynthetic process] GO:0046986 [negative regulation of hemoglobin biosynthetic process] GO:0055072 [iron ion homeostasis] Show all	630 aa 71.1 kDa	No	0
EIF2AK1-004 ENSP00000397590 ENST00000446699	C9J7U7 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18.5 kDa	No	0
EIF2AK1-011 ENSP00000392734 ENST00000422786	H7C033 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 7.5 kDa	Yes	0