Tissue expression of SEPHS1 - Summary - The Human Protein Atlas

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SEPHS1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SEPHS1
Gene description	Selenophosphate synthetase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear expression.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA037645
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SEPHS1 (HGNC Symbol)
Synonyms	SPS, SPS1
Description	Selenophosphate synthetase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]
Chromosome	10
Cytoband	p13
Chromosome location (bp)	13317424 - 13348298
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086475 (version 83.38)
Entrez gene	22929
UniProt	P49903 (UniProt - Evidence at protein level)
neXtProt	NX_P49903
Antibodypedia	SEPHS1 antibodies

PROTEIN BROWSER

SEPHS1-001	SEPHS1-002	SEPHS1-003	SEPHS1-004	SEPHS1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEPHS1-001 ENSP00000367893 ENST00000327347	P49903 [Direct mapping] Selenide, water dikinase 1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004756 [selenide, water dikinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006464 [cellular protein modification process] GO:0016310 [phosphorylation] GO:0031965 [nuclear membrane] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] Show all	392 aa 42.9 kDa	No	0
SEPHS1-002 ENSP00000367877 ENST00000378614	P49903 [Direct mapping] Selenide, water dikinase 1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004756 [selenide, water dikinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006464 [cellular protein modification process] GO:0016310 [phosphorylation] GO:0031965 [nuclear membrane] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] Show all	321 aa 35.5 kDa	No	0
SEPHS1-003 ENSP00000401732 ENST00000413411	Q5T5U6 [Direct mapping] Selenide, water dikinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	166 aa 18.5 kDa	No	0
SEPHS1-004 ENSP00000400418 ENST00000425947	Q5T5U7 [Direct mapping] Selenide, water dikinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	92 aa 10.1 kDa	No	0
SEPHS1-201 ENSP00000441119 ENST00000545675	P49903 [Direct mapping] Selenide, water dikinase 1 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004756 [selenide, water dikinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006464 [cellular protein modification process] GO:0016310 [phosphorylation] GO:0031965 [nuclear membrane] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] Show all	325 aa 35.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.