Cell atlas - PPEF1 - The Human Protein Atlas

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PPEF1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Plasma membrane

Human cell
	Microtubules
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PPEF1
Gene description	Protein phosphatase, EF-hand calcium binding domain 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytokinetic bridge.
RNA cell category	Cell line enhanced (HeLa, A549)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (uncertain)
Additional location	In addition localized to the Cytokinetic bridge (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA034577
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HeLa, A549) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytokinetic bridge.

Main location

Plasma membrane (uncertain)

Additional location

Cytokinetic bridge (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034577	HeLa	Plasma membrane
	HPA034577	HeLa	Cytokinetic bridge	Intensity	Intensity
	HPA034577	U-2 OS	Plasma membrane
	HPA034577	U-251 MG	Plasma membrane

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	PPEF1 (HGNC Symbol)
Synonyms	PPEF, PPP7CA
Description	Protein phosphatase, EF-hand calcium binding domain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p22.13
Chromosome location (bp)	18675909 - 18827921
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086717 (version 83.38)
Entrez gene	5475
UniProt	O14829 (UniProt - Evidence at protein level)
neXtProt	NX_O14829
Antibodypedia	PPEF1 antibodies

PROTEIN BROWSER

PPEF1-001	PPEF1-004	PPEF1-007	PPEF1-008	PPEF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPEF1-001 ENSP00000354871 ENST00000361511	O14829 [Direct mapping] Serine/threonine-protein phosphatase with EF-hands 1 A0A024RBZ9 [Target identity:100%; Query identity:100%] Serine/threonine-protein phosphatase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005506 [iron ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0007603 [phototransduction, visible light] GO:0016056 [rhodopsin mediated signaling pathway] GO:0016787 [hydrolase activity] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030145 [manganese ion binding] GO:0050906 [detection of stimulus involved in sensory perception] Show all	653 aa 75.8 kDa	No	0
PPEF1-004 ENSP00000418623 ENST00000496075	F8WC69 [Direct mapping] Serine/threonine-protein phosphatase Show all	Predicted intracellular proteins Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016787 [hydrolase activity] Show all	179 aa 20.7 kDa	No	0
PPEF1-007 ENSP00000419948 ENST00000472826	C9JY08 [Direct mapping] Serine/threonine-protein phosphatase with EF-hands 1 Show all	Predicted intracellular proteins Show all		96 aa 11.3 kDa	No	0
PPEF1-008 ENSP00000419273 ENST00000470157	H7C592 [Direct mapping] Serine/threonine-protein phosphatase with EF-hands 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	115 aa 13.4 kDa	No	0
PPEF1-201 ENSP00000341892 ENST00000349874	O14829 [Direct mapping] Serine/threonine-protein phosphatase with EF-hands 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005506 [iron ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0007603 [phototransduction, visible light] GO:0016056 [rhodopsin mediated signaling pathway] GO:0016787 [hydrolase activity] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030145 [manganese ion binding] GO:0050906 [detection of stimulus involved in sensory perception] Show all	591 aa 68.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.