Expression of ADAMTS2 in cancer - Summary

CANCER ATLAS

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 2

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028444

GENE INFORMATION
Gene name	ADAMTS2 (HGNC Symbol)
Synonyms	ADAM-TS2, ADAMTS-3, hPCPNI, NPI, PCINP
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	179110851 - 179345430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087116 (version 83.38)
Entrez gene	9509
UniProt	O95450 (UniProt - Evidence at transcript level)
neXtProt	NX_O95450
Antibodypedia	ADAMTS2 antibodies

PROTEIN BROWSER

ADAMTS2-001	ADAMTS2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS2-001 ENSP00000251582 ENST00000251582	O95450 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016485 [protein processing] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030324 [lung development] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0043588 [skin development] Show all	1211 aa 134.8 kDa	Yes	0
ADAMTS2-002 ENSP00000274609 ENST00000274609	O95450 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] Show all	566 aa 61.8 kDa	Yes	0