Cell atlas - LPCAT2 - The Human Protein Atlas

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LPCAT2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Lipid droplets

Human cell
	Endoplasmic Reticulum
	Vesicles

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GENERAL INFORMATION
Gene name	LPCAT2
Gene description	Lysophosphatidylcholine acyltransferase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum & lipid droplets.
RNA cell category	Cell line enhanced (HMC-1, WM-115, CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (validated), Lipid droplets (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA007891
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, WM-115, CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum & lipid droplets.

Main location

Endoplasmic reticulum (validated), Lipid droplets (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007891	A-431	Endoplasmic reticulum
	HPA007891	A-431	Lipid droplets
	HPA007891	U-2 OS	No staining
	HPA007891	U-251 MG	Endoplasmic reticulum
	HPA007891	U-251 MG	Lipid droplets

GENE INFORMATION
Gene name	LPCAT2 (HGNC Symbol)
Synonyms	AGPAT11, AYTL1, FLJ20481, LysoPAFAT
Description	Lysophosphatidylcholine acyltransferase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	55508998 - 55586670
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087253 (version 83.38)
Entrez gene	54947
UniProt	Q7L5N7 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L5N7
Antibodypedia	LPCAT2 antibodies

PROTEIN BROWSER

LPCAT2-001	LPCAT2-004	LPCAT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPCAT2-001 ENSP00000262134 ENST00000262134	Q7L5N7 [Direct mapping] Lysophosphatidylcholine acyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005795 [Golgi stack] GO:0005811 [lipid particle] GO:0006644 [phospholipid metabolic process] GO:0006663 [platelet activating factor biosynthetic process] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047184 [1-acylglycerophosphocholine O-acyltransferase activity] GO:0047192 [1-alkylglycerophosphocholine O-acetyltransferase activity] GO:0061024 [membrane organization] Show all	544 aa 60.2 kDa	No	2
LPCAT2-004 ENSP00000457496 ENST00000564084	H3BU68 [Direct mapping] Lysophosphatidylcholine acyltransferase 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016746 [transferase activity, transferring acyl groups] Show all	188 aa 21.4 kDa	No	0
LPCAT2-201 ENSP00000483225 ENST00000615823	A0A087X0A3 [Direct mapping] Lysophosphatidylcholine acyltransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	252 aa 28.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.