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Carcinoid showed moderate to strong cytoplasmic and/or membranous staining. A subset of tumor cells in rare cases of glioma exhibited moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
Weak to moderate cytoplasmic staining in a few cases of most malignancies Neuropil was strongly positive in malignant gliomas.
GENE INFORMATION
Gene name
GNAO1 (HGNC Symbol)
Synonyms
G-ALPHA-o
Description
Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]