Expression of SH3BP2 in cancer - Summary

CANCER ATLAS

Gene description

SH3-domain binding protein 2

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036790

GENE INFORMATION
Gene name	SH3BP2 (HGNC Symbol)
Synonyms	CRBM, RES4-23
Description	SH3-domain binding protein 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	2793023 - 2841098
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087266 (version 83.38)
Entrez gene	6452
UniProt	P78314 (UniProt - Evidence at protein level)
neXtProt	NX_P78314
Antibodypedia	SH3BP2 antibodies

PROTEIN BROWSER

SH3BP2-001	SH3BP2-002	SH3BP2-006	SH3BP2-007	SH3BP2-010	SH3BP2-012	SH3BP2-014	SH3BP2-017	SH3BP2-018	SH3BP2-019	SH3BP2-201	SH3BP2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SH3BP2-001 ENSP00000409746 ENST00000452765	P78314 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0009967 [positive regulation of signal transduction] Show all	561 aa 62.2 kDa	No	0
SH3BP2-002 ENSP00000403231 ENST00000435136	P78314 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0009967 [positive regulation of signal transduction] Show all	561 aa 62.2 kDa	No	0
SH3BP2-006 ENSP00000424846 ENST00000511747	P78314 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0009967 [positive regulation of signal transduction] Show all	561 aa 62.2 kDa	No	0
SH3BP2-007 ENSP00000348685 ENST00000356331	P78314 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0009967 [positive regulation of signal transduction] Show all	561 aa 62.2 kDa	No	0
SH3BP2-010 ENSP00000422796 ENST00000503219	D6RAB4 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		142 aa 16.3 kDa	No	0
SH3BP2-012 ENSP00000423275 ENST00000504294	D6R995 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 19.5 kDa	No	0
SH3BP2-014 ENSP00000424917 ENST00000508385	D6RER9 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 21.4 kDa	No	0
SH3BP2-017 ENSP00000424105 ENST00000512014	D6RBL6 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		194 aa 22.1 kDa	No	0
SH3BP2-018 ENSP00000423823 ENST00000513095	D6RC64 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.6 kDa	No	0
SH3BP2-019 ENSP00000425537 ENST00000502260	D6RAB4 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		142 aa 16.3 kDa	No	0
SH3BP2-201 ENSP00000388152 ENST00000442312	P78314 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0009967 [positive regulation of signal transduction] Show all	589 aa 65.3 kDa	No	0
SH3BP2-202 ENSP00000422168 ENST00000503393	P78314 [Direct mapping] SH3 domain-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0009967 [positive regulation of signal transduction] GO:0017124 [SH3 domain binding] Show all	618 aa 68.1 kDa	No	0