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Several cases of colorectal cancers along with a few cases of testicular and head and neck cancers showed moderate nucleolar positivity. Additional membranous positivity was observed in a few cases of colorectal cancers. Remaining malignant tissues were weakly stained or negative.
GENE INFORMATION
Gene name
NOP14 (HGNC Symbol)
Synonyms
C4orf9, NOL14, RES4-25, UTP2
Description
NOP14 nucleolar protein (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000472 [endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0000480 [endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006364 [rRNA processing] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0030490 [maturation of SSU-rRNA] GO:0030515 [snoRNA binding] GO:0030686 [90S preribosome] GO:0030692 [Noc4p-Nop14p complex] GO:0032040 [small-subunit processome] GO:0042274 [ribosomal small subunit biogenesis] GO:0044822 [poly(A) RNA binding]
