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The majority of malignancies showed weak to moderate cytoplasmic and occasional membranous immunoreactivity. A few ovarian, urothelial and basal cell carcinomas were strongly stained. Testicular cancers along with most malignant lymphomas, gliomas and stomach cancers were negative.
This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein. [provided by RefSeq, Jul 2008]