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The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001829 [trophectodermal cell differentiation] GO:0001942 [hair follicle development] GO:0003334 [keratinocyte development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007267 [cell-cell signaling] GO:0008584 [male gonad development] GO:0019827 [stem cell population maintenance] GO:0021877 [forebrain neuron fate commitment] GO:0021987 [cerebral cortex development] GO:0030154 [cell differentiation] GO:0030718 [germ-line stem cell population maintenance] GO:0035019 [somatic stem cell population maintenance] GO:0040029 [regulation of gene expression, epigenetic] GO:0042127 [regulation of cell proliferation] GO:0043588 [skin development] GO:0045682 [regulation of epidermis development] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0048733 [sebaceous gland development] GO:0060598 [dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis] GO:0060750 [epithelial cell proliferation involved in mammary gland duct elongation]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0042127 [regulation of cell proliferation]