Cell atlas - RFX2 - The Human Protein Atlas

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RFX2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Nucleoplasm

Human cell
	Cytosol
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RFX2
Gene description	Regulatory factor X, 2 (influences HLA class II expression)
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol, the Golgi apparatus & nucleoplasm.
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Golgi apparatus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048969
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol, the Golgi apparatus & nucleoplasm.

Main location

Nucleoplasm (approved), Golgi apparatus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048969	MCF7	Nucleoplasm
			Golgi apparatus
			Cytosol
	HPA048969	RT4	Nucleoplasm
	HPA048969	RT4	Golgi apparatus
	HPA048969	U-2 OS	Nucleoplasm
	HPA048969	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	RFX2 (HGNC Symbol)
Synonyms	FLJ14226
Description	Regulatory factor X, 2 (influences HLA class II expression) (HGNC Symbol)
Entrez gene summary	This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	5993164 - 6199572
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087903 (version 83.38)
Entrez gene	5990
UniProt	P48378 (UniProt - Evidence at transcript level)
neXtProt	NX_P48378
Antibodypedia	RFX2 antibodies

PROTEIN BROWSER

RFX2-002	RFX2-003	RFX2-004	RFX2-005	RFX2-006	RFX2-010	RFX2-011	RFX2-012	RFX2-013	RFX2-014	RFX2-018	RFX2-019	RFX2-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RFX2-002 ENSP00000306335 ENST00000303657	P48378 [Direct mapping] DNA-binding protein RFX2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	723 aa 80 kDa	No	0
RFX2-003 ENSP00000467166 ENST00000592546	P48378 [Direct mapping] DNA-binding protein RFX2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	698 aa 77.3 kDa	No	0
RFX2-004 ENSP00000352076 ENST00000359161	P48378 [Direct mapping] DNA-binding protein RFX2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	723 aa 80 kDa	No	0
RFX2-005 ENSP00000468036 ENST00000592473	K7EQY9 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	111 aa 11.5 kDa	No	0
RFX2-006 ENSP00000466890 ENST00000593241	K7ENC9 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	94 aa 10 kDa	No	0
RFX2-010 ENSP00000465135 ENST00000587181	K7EJE4 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	99 aa 10.4 kDa	No	0
RFX2-011 ENSP00000468561 ENST00000592281	K7ES56 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	105 aa 11 kDa	No	0
RFX2-012 ENSP00000467979 ENST00000586302	K7EQU2 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	169 aa 17.3 kDa	No	0
RFX2-013 ENSP00000467736 ENST00000586806	K7EQA0 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	147 aa 16.8 kDa	No	0
RFX2-014 ENSP00000465122 ENST00000587321	K7EJD4 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	33 aa 3.9 kDa	No	0
RFX2-018 ENSP00000466177 ENST00000589742	K7ELQ7 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	98 aa 11 kDa	No	0
RFX2-019 ENSP00000466028 ENST00000589340	K7ELD5 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	180 aa 19.7 kDa	No	0
RFX2-021 ENSP00000464826 ENST00000592883	K7EIN5 [Direct mapping] DNA-binding protein RFX2 Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	143 aa 14.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.