Tissue expression of PTPN4 - Summary - The Human Protein Atlas

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PTPN4

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PTPN4
Gene description	Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA019351
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PTPN4 (HGNC Symbol)
Synonyms	PTPMEG
Description	Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q14.2
Chromosome location (bp)	119759631 - 119983818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088179 (version 83.38)
Entrez gene	5775
UniProt	P29074 (UniProt - Evidence at protein level)
neXtProt	NX_P29074
Antibodypedia	PTPN4 antibodies

PROTEIN BROWSER

PTPN4-001	PTPN4-008	PTPN4-010	PTPN4-011	PTPN4-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPN4-001 ENSP00000263708 ENST00000263708	P29074 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 4 A0A024RAE8 [Target identity:100%; Query identity:100%] Tyrosine-protein phosphatase non-receptor type Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006470 [protein dephosphorylation] GO:0008092 [cytoskeletal protein binding] GO:0009898 [cytoplasmic side of plasma membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	926 aa 105.9 kDa	No	0
PTPN4-008 ENSP00000394706 ENST00000441089	J3KQD3 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	219 aa 25.1 kDa	No	0
PTPN4-010 ENSP00000387457 ENST00000431283	J3QT41 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 4 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	197 aa 21.7 kDa	No	0
PTPN4-011 ENSP00000405763 ENST00000420482	J3KQP5 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 4 Show all	Predicted intracellular proteins Show all	GO:0005856 [cytoskeleton] Show all	75 aa 8.7 kDa	No	0
PTPN4-012 ENSP00000438445 ENST00000488279	F5H020 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 4 Show all	Predicted intracellular proteins Show all	GO:0005856 [cytoskeleton] Show all	161 aa 18.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.