Cell atlas - KHSRP - The Human Protein Atlas

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KHSRP

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KHSRP
Gene description	KH-type splicing regulatory protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Mouse	Localized to the Nucleus in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA034739 , HPA056518
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034739	A-431	Nucleoplasm
	HPA034739	U-2 OS	Nucleoplasm
	HPA034739	U-251 MG	Nucleoplasm
	HPA056518	A-431	Nucleoplasm
	HPA056518	U-2 OS	Nucleoplasm
	HPA056518	U-251 MG	Nucleoplasm

MOUSE CELLS

Main location

Nucleus

Mouse gene

ENSMUSG00000007670 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA056518	NIH 3T3	Nucleus

GENE INFORMATION
Gene name	KHSRP (HGNC Symbol)
Synonyms	FBP2, FUBP2, KSRP
Description	KH-type splicing regulatory protein (HGNC Symbol)
Entrez gene summary	The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	6413348 - 6424794
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088247 (version 83.38)
Entrez gene	8570
UniProt	Q92945 (UniProt - Evidence at protein level)
neXtProt	NX_Q92945
Antibodypedia	KHSRP antibodies

PROTEIN BROWSER

KHSRP-001	KHSRP-002	KHSRP-003	KHSRP-004	KHSRP-005	KHSRP-008	KHSRP-009	KHSRP-011	KHSRP-012	KHSRP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KHSRP-001 ENSP00000381216 ENST00000398148	Q92945 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000375 [RNA splicing, via transesterification reactions] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006397 [mRNA processing] GO:0006402 [mRNA catabolic process] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0010494 [cytoplasmic stress granule] GO:0016020 [membrane] GO:0030425 [dendrite] GO:0043025 [neuronal cell body] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] GO:2000628 [regulation of miRNA metabolic process] Show all	711 aa 73.1 kDa	No	0
KHSRP-002 ENSP00000471262 ENST00000599395	M0R0I5 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	279 aa 29.3 kDa	No	0
KHSRP-003 ENSP00000469830 ENST00000595548	M0QYH3 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005654 [nucleoplasm] Show all	169 aa 18 kDa	No	0
KHSRP-004 ENSP00000469431 ENST00000595258	M0QXW7 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005654 [nucleoplasm] Show all	116 aa 12.1 kDa	No	0
KHSRP-005 ENSP00000473254 ENST00000595223	M0R3J3 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	269 aa 28 kDa	No	0
KHSRP-008 ENSP00000472347 ENST00000594496	M0R263 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 14.9 kDa	No	0
KHSRP-009 ENSP00000471146 ENST00000600480	M0R0C6 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 18.5 kDa	No	0
KHSRP-011 ENSP00000472328 ENST00000597656	M0R251 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.4 kDa	No	0
KHSRP-012 ENSP00000469804 ENST00000594745	M0QYG1 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 12.3 kDa	No	0
KHSRP-201 ENSP00000478033 ENST00000619396	A0A087WTP3 [Direct mapping] Far upstream element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	711 aa 73 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.