Cell atlas - ATRN - The Human Protein Atlas

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ATRN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ATRN
Gene description	Attractin
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA008853
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008853	A-431	Cytosol
	HPA008853	U-2 OS	Cytosol
	HPA008853	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ATRN (HGNC Symbol)
Synonyms	DPPT-L, MGCA
Description	Attractin (HGNC Symbol)
Entrez gene summary	Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other two isoforms are secreted proteins involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, May 2011]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	3471040 - 3651122
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088812 (version 83.38)
Entrez gene	8455
UniProt	O75882 (UniProt - Evidence at protein level)
neXtProt	NX_O75882
Antibodypedia	ATRN antibodies

PROTEIN BROWSER

ATRN-001	ATRN-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATRN-001 ENSP00000416587 ENST00000446916	O75882 [Direct mapping] Attractin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] Show all	1272 aa 141.4 kDa	No	1
ATRN-002 ENSP00000262919 ENST00000262919	O75882 [Direct mapping] Attractin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0016020 [membrane] GO:0021549 [cerebellum development] GO:0030246 [carbohydrate binding] GO:0040014 [regulation of multicellular organism growth] GO:0042552 [myelination] GO:0043473 [pigmentation] GO:0070062 [extracellular exosome] Show all	1429 aa 158.5 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.