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FKBP1A

CANCER ATLAS

Gene description

 FK506 binding protein 1A, 12kDa

Protein class

 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051798
CAB004639

GENE INFORMATION

Gene name

 FKBP1A (HGNC Symbol)

Synonyms

 FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PPIASE

Description

 FK506 binding protein 1A, 12kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 1368978 - 1393172

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088832 (version 83.38)

Entrez gene

 2280

UniProt

 P62942 (UniProt - Evidence at protein level)

neXtProt

 NX_P62942

Antibodypedia

 FKBP1A antibodies

PROTEIN BROWSER
FKBP1A-001
FKBP1A-002
FKBP1A-004
FKBP1A-005
FKBP1A-009
FKBP1A-201
FKBP1A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP1A-001
ENSP00000383003
ENST00000400137
P62942 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP1A
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004871 [signal transducer activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005527 [macrolide binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006936 [muscle contraction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008144 [drug binding]
GO:0010039 [response to iron ion]
GO:0014802 [terminal cisterna]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0022417 [protein maturation by protein folding]
GO:0030018 [Z disc]
GO:0030544 [Hsp70 protein binding]
GO:0031000 [response to caffeine]
GO:0031012 [extracellular matrix]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032092 [positive regulation of protein binding]
GO:0032513 [negative regulation of protein phosphatase type 2B activity]
GO:0032880 [regulation of protein localization]
GO:0032925 [regulation of activin receptor signaling pathway]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0042026 [protein refolding]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043206 [extracellular fibril organization]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043679 [axon terminus]
GO:0044325 [ion channel binding]
GO:0046332 [SMAD binding]
GO:0048185 [activin binding]
GO:0050776 [regulation of immune response]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060347 [heart trabecula formation]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:1902991 [regulation of amyloid precursor protein catabolic process]
GO:1990000 [amyloid fibril formation]
Show all
 108 aa
12 kDa 		No 0
FKBP1A-002
ENSP00000371138
ENST00000381719
P62942 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP1A
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003007 [heart morphogenesis]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004871 [signal transducer activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005527 [macrolide binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0014802 [terminal cisterna]
GO:0016020 [membrane]
GO:0022417 [protein maturation by protein folding]
GO:0030018 [Z disc]
GO:0031012 [extracellular matrix]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032092 [positive regulation of protein binding]
GO:0032513 [negative regulation of protein phosphatase type 2B activity]
GO:0032880 [regulation of protein localization]
GO:0032925 [regulation of activin receptor signaling pathway]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0042026 [protein refolding]
GO:0042110 [T cell activation]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043206 [extracellular fibril organization]
GO:0044325 [ion channel binding]
GO:0046332 [SMAD binding]
GO:0048185 [activin binding]
GO:0050776 [regulation of immune response]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060347 [heart trabecula formation]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:1902991 [regulation of amyloid precursor protein catabolic process]
GO:1990000 [amyloid fibril formation]
Show all
 108 aa
12 kDa 		No 0
FKBP1A-004
ENSP00000371143
ENST00000381724
Q5W0X3 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 103 aa
11.4 kDa 		No 0
FKBP1A-005
ENSP00000371134
ENST00000381715
Q5W0X3 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 103 aa
11.4 kDa 		No 0
FKBP1A-009
ENSP00000482758
ENST00000614856
A0A087WZM5 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0016021 [integral component of membrane]
GO:0061077 [chaperone-mediated protein folding]
Show all
 129 aa
14.9 kDa 		No 1
FKBP1A-201
ENSP00000409863
ENST00000439640
Q1JUQ5 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 92 aa
10.1 kDa 		No 0
FKBP1A-202
ENSP00000478093
ENST00000618612
A0A087WTS4 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP1A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0061077 [chaperone-mediated protein folding]
Show all
 97 aa
10.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.