Cell atlas - SLC4A11 - The Human Protein Atlas

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SLC4A11

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	SLC4A11
Gene description	Solute carrier family 4, sodium borate transporter, member 11
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles.
RNA cell category	Cell line enhanced (HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain)
Additional location	In addition localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 2 antibodies. HPA018120 , HPA058377
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles.

Main location

Nucleoplasm (uncertain)

Additional location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018120	A-431	Nucleoplasm
	HPA018120	A-431	Vesicles
	HPA018120	U-2 OS	Nucleoplasm
	HPA018120	U-2 OS	Aggresome
	HPA018120	U-251 MG	Nucleoplasm
	HPA018120	U-251 MG	Vesicles
	HPA058377	A-431	Nucleoplasm
	HPA058377	Hep G2	No staining
	HPA058377	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	SLC4A11 (HGNC Symbol)
Synonyms	BTR1, CDPD1, CHED2, dJ794I6.2, FECD4, NaBC1
Description	Solute carrier family 4, sodium borate transporter, member 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	3227417 - 3239190
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088836 (version 83.38)
Entrez gene	83959
UniProt	Q8NBS3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NBS3
Antibodypedia	SLC4A11 antibodies

PROTEIN BROWSER

SLC4A11-001	SLC4A11-002	SLC4A11-003	SLC4A11-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC4A11-001 ENSP00000369399 ENST00000380059	Q8NBS3 [Direct mapping] Sodium bicarbonate transporter-like protein 11 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005272 [sodium channel activity] GO:0005452 [inorganic anion exchanger activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006820 [anion transport] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015252 [hydrogen ion channel activity] GO:0015293 [symporter activity] GO:0015701 [bicarbonate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030003 [cellular cation homeostasis] GO:0035445 [borate transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042044 [fluid transport] GO:0046713 [borate transport] GO:0046715 [borate transmembrane transporter activity] GO:0046983 [protein dimerization activity] GO:0050801 [ion homeostasis] GO:0051453 [regulation of intracellular pH] Show all	918 aa 103.1 kDa	No	>9
SLC4A11-002 ENSP00000369396 ENST00000380056	Q8NBS3 [Direct mapping] Sodium bicarbonate transporter-like protein 11 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005272 [sodium channel activity] GO:0005452 [inorganic anion exchanger activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006820 [anion transport] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015252 [hydrogen ion channel activity] GO:0015293 [symporter activity] GO:0015701 [bicarbonate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030003 [cellular cation homeostasis] GO:0035445 [borate transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042044 [fluid transport] GO:0046713 [borate transport] GO:0046715 [borate transmembrane transporter activity] GO:0046983 [protein dimerization activity] GO:0051453 [regulation of intracellular pH] Show all	891 aa 99.6 kDa	No	>9
SLC4A11-003 ENSP00000441370 ENST00000539553	Q8NBS3 [Direct mapping] Sodium bicarbonate transporter-like protein 11 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005272 [sodium channel activity] GO:0005452 [inorganic anion exchanger activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006820 [anion transport] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015252 [hydrogen ion channel activity] GO:0015293 [symporter activity] GO:0015701 [bicarbonate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030003 [cellular cation homeostasis] GO:0035445 [borate transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042044 [fluid transport] GO:0046713 [borate transport] GO:0046715 [borate transmembrane transporter activity] GO:0046983 [protein dimerization activity] GO:0051453 [regulation of intracellular pH] Show all	875 aa 98.2 kDa	No	>9
SLC4A11-007 ENSP00000404271 ENST00000437836	V9GXZ2 [Direct mapping] Sodium bicarbonate transporter-like protein 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005887 [integral component of plasma membrane] GO:0051453 [regulation of intracellular pH] GO:0098656 [anion transmembrane transport] Show all	105 aa 11.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.