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XRN2

GENERAL INFORMATION

Gene name

 XRN2

Gene description

 5'-3' exoribonuclease 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA047118
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 XRN2

Synonyms

Description

 5'-3' exoribonuclease 2 (HGNC Symbol)

Entrez gene summary

 This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p11.22

Chromosome location (bp)

 21303304 - 21389827

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088930 (version 83.38)

Entrez gene

 22803

UniProt

 Q9H0D6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0D6

Antibodypedia

 XRN2 antibodies

PROTEIN BROWSER
XRN2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XRN2-001
ENSP00000366396
ENST00000377191
Q9H0D6 [Direct mapping]
5'-3' exoribonuclease 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000738 [DNA catabolic process, exonucleolytic]
GO:0001147 [transcription termination site sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0004518 [nuclease activity]
GO:0004527 [exonuclease activity]
GO:0004534 [5'-3' exoribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006353 [DNA-templated transcription, termination]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0006401 [RNA catabolic process]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0008409 [5'-3' exonuclease activity]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016070 [RNA metabolic process]
GO:0016235 [aggresome]
GO:0044822 [poly(A) RNA binding]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 950 aa
108.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.