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RPL6

GENERAL INFORMATION

Gene name

 RPL6

Gene description

 Ribosomal protein L6

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA068418
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RPL6 (HGNC Symbol)

Synonyms

 L6, TAXREB107, TXREB1

Description

 Ribosomal protein L6 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.13

Chromosome location (bp)

 112405190 - 112418838

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089009 (version 83.38)

Entrez gene

 6128

UniProt

 Q02878 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02878

Antibodypedia

 RPL6 antibodies

PROTEIN BROWSER
RPL6-001
RPL6-002
RPL6-008
RPL6-009
RPL6-011
RPL6-012
RPL6-016
RPL6-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPL6-001
ENSP00000202773
ENST00000202773
Q02878 [Direct mapping]
60S ribosomal protein L6
A0A024RBK3 [Target identity:100%; Query identity:100%]
60S ribosomal protein L6
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Ribosomal proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000027 [ribosomal large subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
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 288 aa
32.7 kDa 		No 0
RPL6-002
ENSP00000403172
ENST00000424576
Q02878 [Direct mapping]
60S ribosomal protein L6
A0A024RBK3 [Target identity:100%; Query identity:100%]
60S ribosomal protein L6
Show all
Ribosomal proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000027 [ribosomal large subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 288 aa
32.7 kDa 		No 0
RPL6-008
ENSP00000446883
ENST00000549847
F8VZ45 [Direct mapping]
60S ribosomal protein L6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 159 aa
17.8 kDa 		No 0
RPL6-009
ENSP00000446859
ENST00000548343
F8VZA3 [Direct mapping]
60S ribosomal protein L6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 105 aa
11.6 kDa 		No 0
RPL6-011
ENSP00000448570
ENST00000550238
F8VR69 [Direct mapping]
60S ribosomal protein L6
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 64 aa
7.3 kDa 		No 0
RPL6-012
ENSP00000448067
ENST00000551291
F8VU16 [Direct mapping]
60S ribosomal protein L6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 120 aa
13.4 kDa 		No 0
RPL6-016
ENSP00000449486
ENST00000553213
F8VWR1 [Direct mapping]
60S ribosomal protein L6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 118 aa
13.2 kDa 		No 0
RPL6-017
ENSP00000476161
ENST00000550566
U3KQR5 [Direct mapping]
60S ribosomal protein L6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 160 aa
17.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.