Cell atlas - SIRPG - The Human Protein Atlas

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SIRPG

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SIRPG
Gene description	Signal-regulatory protein gamma
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (NB-4, RT4, THP-1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NB-4, RT4, THP-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SIRPG (HGNC Symbol)
Synonyms	bA77C3.1, CD172g, SIRP-B2, SIRPB2, SIRPgamma
Description	Signal-regulatory protein gamma (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	1629152 - 1657779
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089012 (version 83.38)
Entrez gene	55423
UniProt	Q9P1W8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P1W8
Antibodypedia	SIRPG antibodies

PROTEIN BROWSER

SIRPG-001	SIRPG-004	SIRPG-005	SIRPG-006	SIRPG-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIRPG-001 ENSP00000370992 ENST00000381580	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	354 aa 39 kDa	No	1
SIRPG-004 ENSP00000342759 ENST00000344103	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	170 aa 18.5 kDa	Yes	1
SIRPG-005 ENSP00000305529 ENST00000303415	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	387 aa 42.5 kDa	Yes	1
SIRPG-006 ENSP00000216927 ENST00000216927	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	276 aa 30 kDa	Yes	1
SIRPG-201 ENSP00000370995 ENST00000381583	Q9P1W8 [Direct mapping] Signal-regulatory protein gamma Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0035556 [intracellular signal transduction] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] Show all	276 aa 30 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.