Expression of SLC8B1 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

Protein class

Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040668

GENE INFORMATION
Gene name	SLC8B1 (HGNC Symbol)
Synonyms	FLJ22233, NCKX6, NCLX, SLC24A6
Description	Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 (HGNC Symbol)
Entrez gene summary	SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q24.13
Chromosome location (bp)	113298759 - 113359493
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089060 (version 83.38)
Entrez gene	80024
UniProt	Q6J4K2 (UniProt - Evidence at protein level)
neXtProt	NX_Q6J4K2
Antibodypedia	SLC8B1 antibodies

PROTEIN BROWSER

SLC8B1-001	SLC8B1-002	SLC8B1-006	SLC8B1-008	SLC8B1-011	SLC8B1-014	SLC8B1-015	SLC8B1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC8B1-001 ENSP00000447091 ENST00000552014	Q6J4K2 [Direct mapping] Sodium/potassium/calcium exchanger 6, mitochondrial Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005432 [calcium:sodium antiporter activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006851 [mitochondrial calcium ion transport] GO:0016021 [integral component of membrane] GO:0030061 [mitochondrial crista] GO:0032592 [integral component of mitochondrial membrane] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0042593 [glucose homeostasis] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0050796 [regulation of insulin secretion] GO:0050896 [response to stimulus] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051560 [mitochondrial calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086036 [regulation of cardiac muscle cell membrane potential] GO:0086038 [calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential] Show all	584 aa 64.2 kDa	Yes	>9
SLC8B1-002 ENSP00000450081 ENST00000546737	Q6J4K2 [Direct mapping] Sodium/potassium/calcium exchanger 6, mitochondrial Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005432 [calcium:sodium antiporter activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006851 [mitochondrial calcium ion transport] GO:0016021 [integral component of membrane] GO:0030061 [mitochondrial crista] GO:0032592 [integral component of mitochondrial membrane] GO:0042593 [glucose homeostasis] GO:0042803 [protein homodimerization activity] GO:0050796 [regulation of insulin secretion] GO:0050896 [response to stimulus] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051560 [mitochondrial calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0086036 [regulation of cardiac muscle cell membrane potential] GO:0086038 [calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential] Show all	528 aa 58.1 kDa	Yes	9
SLC8B1-006 ENSP00000447585 ENST00000550047	A0A0B4J252 [Direct mapping] Sodium/potassium/calcium exchanger 6, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	99 aa 10.8 kDa	No	3
SLC8B1-008 ENSP00000447972 ENST00000549372	F8VTU4 [Direct mapping] Sodium/potassium/calcium exchanger 6, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		103 aa 11.2 kDa	Yes	0
SLC8B1-011 ENSP00000449519 ENST00000549069	F8VW44 [Direct mapping] Sodium/potassium/calcium exchanger 6, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	143 aa 15.4 kDa	No	3
SLC8B1-014 ENSP00000449448 ENST00000548186	F8VWW9 [Direct mapping] Sodium/potassium/calcium exchanger 6, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	131 aa 14.2 kDa	Yes	1
SLC8B1-015 ENSP00000448703 ENST00000549181	F8VR99 [Direct mapping] Sodium/potassium/calcium exchanger 6, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	231 aa 24.8 kDa	Yes	3
SLC8B1-201 ENSP00000202831 ENST00000202831	Q6J4K2 [Direct mapping] Sodium/potassium/calcium exchanger 6, mitochondrial Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005432 [calcium:sodium antiporter activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006851 [mitochondrial calcium ion transport] GO:0016021 [integral component of membrane] GO:0030061 [mitochondrial crista] GO:0032592 [integral component of mitochondrial membrane] GO:0042593 [glucose homeostasis] GO:0042803 [protein homodimerization activity] GO:0050796 [regulation of insulin secretion] GO:0050896 [response to stimulus] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051560 [mitochondrial calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0086036 [regulation of cardiac muscle cell membrane potential] GO:0086038 [calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential] Show all	584 aa 64.2 kDa	Yes	>9