Expression of LHX5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

LIM homeobox 5

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053908

GENE INFORMATION
Gene name	LHX5
Synonyms
Description	LIM homeobox 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.13
Chromosome location (bp)	113462034 - 113472280
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000089116 (version 83.38)
Entrez gene	64211
UniProt	Q9H2C1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H2C1
Antibodypedia	LHX5 antibodies

PROTEIN BROWSER

LHX5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHX5-001 ENSP00000261731 ENST00000261731	Q9H2C1 [Direct mapping] LIM/homeobox protein Lhx5 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0021527 [spinal cord association neuron differentiation] GO:0021549 [cerebellum development] GO:0021702 [cerebellar Purkinje cell differentiation] GO:0021766 [hippocampus development] GO:0021846 [cell proliferation in forebrain] GO:0021879 [forebrain neuron differentiation] GO:0021937 [cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation] GO:0042127 [regulation of cell proliferation] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	402 aa 44.4 kDa	No	0