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Several cases of renal cancers along with a few cases of skin, endometrial, urothelial, gastric and pancreatic cancers showed moderate immunoreactivity. Remaining cancer cells were mainly negative.
Several gliomas and cases of carcinoids, breast, colorectal and thyroid cancers displayed moderate cytoplasmic and/or nucleolar positivity. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
TASP1 (HGNC Symbol)
Synonyms
C20orf13, dJ585I14.2, FLJ20212
Description
Taspase, threonine aspartase, 1 (HGNC Symbol)
Entrez gene summary
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
