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PXN

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GENERAL INFORMATION

Gene name

 PXN

Gene description

 Paxillin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the focal adhesion sites. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Focal adhesion sites (validated)

Additional location

 In addition localized to the Cytosol (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB003841 , HPA051309
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the focal adhesion sites. In addition localized to the cytosol.

Main location

 Focal adhesion sites (validated)

Additional location

 Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB003841 A-431 Focal adhesion sites
Centrosome
Cytosol
CAB003841 U-2 OS Focal adhesion sites
CAB003841 U-251 MG Focal adhesion sites
Centrosome
Cytosol
HPA051309 A-431 Focal adhesion sites
Cytosol
HPA051309 U-2 OS Focal adhesion sites
Cytosol
HPA051309 U-251 MG Focal adhesion sites
Cytosol

GENE INFORMATION

Gene name

 PXN

Synonyms

Description

 Paxillin (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q24.23

Chromosome location (bp)

 120210439 - 120265771

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089159 (version 83.38)

Entrez gene

 5829

UniProt

 P49023 (UniProt - Evidence at protein level)

neXtProt

 NX_P49023

Antibodypedia

 PXN antibodies

PROTEIN BROWSER
PXN-001
PXN-002
PXN-003
PXN-004
PXN-009
PXN-012
PXN-013
PXN-014
PXN-015
PXN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PXN-001
ENSP00000228307
ENST00000228307
P49023 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0017166 [vinculin binding]
GO:0030027 [lamellipodium]
GO:0034329 [cell junction assembly]
GO:0034614 [cellular response to reactive oxygen species]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
Show all
 591 aa
64.5 kDa 		No 0
PXN-002
ENSP00000391283
ENST00000424649
P49023 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0017166 [vinculin binding]
GO:0030027 [lamellipodium]
GO:0034329 [cell junction assembly]
GO:0034614 [cellular response to reactive oxygen species]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
Show all
 557 aa
61 kDa 		No 0
PXN-003
ENSP00000395536
ENST00000458477
P49023 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0017166 [vinculin binding]
GO:0030027 [lamellipodium]
GO:0034329 [cell junction assembly]
GO:0034614 [cellular response to reactive oxygen species]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0060396 [growth hormone receptor signaling pathway]
Show all
 424 aa
46.6 kDa 		No 0
PXN-004
ENSP00000443887
ENST00000536957
F5GZ78 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0008270 [zinc ion binding]
Show all
 589 aa
64.2 kDa 		No 0
PXN-009
ENSP00000443745
ENST00000543331
F5H836 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007160 [cell-matrix adhesion]
Show all
 177 aa
18.8 kDa 		No 0
PXN-012
ENSP00000446607
ENST00000548912
F8W0G0 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0007160 [cell-matrix adhesion]
Show all
 36 aa
3.8 kDa 		No 0
PXN-013
ENSP00000447180
ENST00000546532
F8W0K8 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0007160 [cell-matrix adhesion]
Show all
 37 aa
3.9 kDa 		No 0
PXN-014
ENSP00000446650
ENST00000552550
F8W1E0 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0007160 [cell-matrix adhesion]
Show all
 31 aa
3.3 kDa 		No 0
PXN-015
ENSP00000449198
ENST00000550795
H0YIE4 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 171 aa
18.2 kDa 		No 0
PXN-201
ENSP00000267257
ENST00000267257
P49023 [Direct mapping]
Paxillin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001725 [stress fiber]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006936 [muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0008360 [regulation of cell shape]
GO:0017166 [vinculin binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0031252 [cell leading edge]
GO:0032403 [protein complex binding]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0051435 [BH4 domain binding]
GO:0060396 [growth hormone receptor signaling pathway]
Show all
 605 aa
66.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.