Expression of BRAP in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

BRCA1 associated protein

Protein class

Predicted intracellular proteins, RAS pathway related proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040357

GENE INFORMATION
Gene name	BRAP (HGNC Symbol)
Synonyms	BRAP2, IMP, RNF52
Description	BRCA1 associated protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.12
Chromosome location (bp)	111642146 - 111685986
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089234 (version 83.38)
Entrez gene	8315
UniProt	Q7Z569 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z569
Antibodypedia	BRAP antibodies

PROTEIN BROWSER

BRAP-001	BRAP-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRAP-001 ENSP00000403524 ENST00000419234	Q7Z569 [Direct mapping] BRCA1-associated protein Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000186 [activation of MAPKK activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008139 [nuclear localization sequence binding] GO:0008270 [zinc ion binding] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0031965 [nuclear membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043130 [ubiquitin binding] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0061630 [ubiquitin protein ligase activity] Show all	592 aa 67.3 kDa	No	0
BRAP-002 ENSP00000330813 ENST00000327551	J3KNN7 [Direct mapping] BRCA1-associated protein Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0043130 [ubiquitin binding] Show all	562 aa 64.3 kDa	No	0