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Cancer tissues showed strong cytoplasmic positivity. Most renal and skin cancers were moderately stained.
GENE INFORMATION
Gene name
ERP29 (HGNC Symbol)
Synonyms
C12orf8, ERp28, ERp29, ERp31, PDI-DB, PDIA9
Description
Endoplasmic reticulum protein 29 (HGNC Symbol)
Entrez gene summary
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]