Fields »
ABOUT
HELP
BLOG
FUS

GENERAL INFORMATION

Gene name

 FUS

Gene description

 FUS RNA binding protein

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA008784 , CAB033036 , CAB058691
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FUS (HGNC Symbol)

Synonyms

 ALS6, FUS1, hnRNP-P2, HNRNPP2, TLS

Description

 FUS RNA binding protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 31180110 - 31194871

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089280 (version 83.38)

Entrez gene

 2521

UniProt

 P35637 (UniProt - Evidence at protein level)

neXtProt

 NX_P35637

Antibodypedia

 FUS antibodies

PROTEIN BROWSER
FUS-001
FUS-008
FUS-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FUS-001
ENSP00000254108
ENST00000254108
P35637 [Direct mapping]
RNA-binding protein FUS
Q6IBQ5 [Target identity:100%; Query identity:100%]
FUS protein; Fusion (Involved in t(1216) in malignant liposarcoma), isoform CRA_a; Fusion, derived from t(12;16) malignant liposarcoma
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005844 [polysome]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0030331 [estrogen receptor binding]
GO:0030425 [dendrite]
GO:0031489 [myosin V binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0044327 [dendritic spine head]
GO:0044822 [poly(A) RNA binding]
GO:0046965 [retinoid X receptor binding]
GO:0046966 [thyroid hormone receptor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071277 [cellular response to calcium ion]
GO:1903506 [regulation of nucleic acid-templated transcription]
Show all
 526 aa
53.4 kDa 		No 0
FUS-008
ENSP00000369594
ENST00000380244
P35637 [Direct mapping]
RNA-binding protein FUS
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:1903506 [regulation of nucleic acid-templated transcription]
Show all
 525 aa
53.4 kDa 		No 0
FUS-016
ENSP00000455282
ENST00000568685
H3BPE7 [Direct mapping]
RNA-binding protein FUS
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
Show all
 527 aa
53.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.