Cell atlas - FXYD5 - The Human Protein Atlas

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FXYD5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	FXYD5
Gene description	FXYD domain containing ion transport regulator 5
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA010817
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA010817	A-431	Endoplasmic reticulum

GENE INFORMATION
Gene name	FXYD5 (HGNC Symbol)
Synonyms	OIT2
Description	FXYD domain containing ion transport regulator 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35154730 - 35169883
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089327 (version 83.38)
Entrez gene	53827
UniProt	Q96DB9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96DB9
Antibodypedia	FXYD5 antibodies

PROTEIN BROWSER

FXYD5-001	FXYD5-002	FXYD5-003	FXYD5-004	FXYD5-007	FXYD5-010	FXYD5-011	FXYD5-012	FXYD5-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FXYD5-001 ENSP00000344254 ENST00000342879	Q96DB9 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0030033 [microvillus assembly] GO:0034220 [ion transmembrane transport] GO:0045296 [cadherin binding] GO:0046588 [negative regulation of calcium-dependent cell-cell adhesion] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	178 aa 19.5 kDa	Yes	1
FXYD5-002 ENSP00000376053 ENST00000392219	Q96DB9 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0030033 [microvillus assembly] GO:0034220 [ion transmembrane transport] GO:0045296 [cadherin binding] GO:0046588 [negative regulation of calcium-dependent cell-cell adhesion] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	178 aa 19.5 kDa	Yes	1
FXYD5-003 ENSP00000376051 ENST00000392217	Q96DB9 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0030033 [microvillus assembly] GO:0034220 [ion transmembrane transport] GO:0045296 [cadherin binding] GO:0046588 [negative regulation of calcium-dependent cell-cell adhesion] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	107 aa 11.9 kDa	No	1
FXYD5-004 ENSP00000444839 ENST00000543307	F5H4X8 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	194 aa 21.1 kDa	Yes	1
FXYD5-007 ENSP00000376052 ENST00000392218	A8MVG1 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0017080 [sodium channel regulator activity] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	96 aa 10.3 kDa	Yes	1
FXYD5-010 ENSP00000467053 ENST00000588699	F5H4X8 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	194 aa 21.1 kDa	Yes	1
FXYD5-011 ENSP00000393848 ENST00000423817	Q96DB9 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0030033 [microvillus assembly] GO:0034220 [ion transmembrane transport] GO:0045296 [cadherin binding] GO:0046588 [negative regulation of calcium-dependent cell-cell adhesion] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	178 aa 19.5 kDa	Yes	1
FXYD5-012 ENSP00000465667 ENST00000590686	Q96DB9 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0030033 [microvillus assembly] GO:0034220 [ion transmembrane transport] GO:0045296 [cadherin binding] GO:0046588 [negative regulation of calcium-dependent cell-cell adhesion] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	178 aa 19.5 kDa	Yes	1
FXYD5-013 ENSP00000443390 ENST00000541435	Q96DB9 [Direct mapping] FXYD domain-containing ion transport regulator 5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0030033 [microvillus assembly] GO:0034220 [ion transmembrane transport] GO:0045296 [cadherin binding] GO:0046588 [negative regulation of calcium-dependent cell-cell adhesion] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	178 aa 19.5 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.