Expression of GANAB in cancer - Summary

CANCER ATLAS

Gene description

Glucosidase, alpha; neutral AB

Protein class

Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026874	HPA061426

GENE INFORMATION
Gene name	GANAB (HGNC Symbol)
Synonyms	G2AN, GluII, KIAA0088
Description	Glucosidase, alpha; neutral AB (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62624826 - 62646726
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089597 (version 83.38)
Entrez gene	23193
UniProt	Q14697 (UniProt - Evidence at protein level)
neXtProt	NX_Q14697
Antibodypedia	GANAB antibodies

PROTEIN BROWSER

GANAB-001	GANAB-002	GANAB-003	GANAB-011	GANAB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GANAB-001 ENSP00000349053 ENST00000356638	Q14697 [Direct mapping] Neutral alpha-glucosidase AB V9HWJ0 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 164nA Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0033919 [glucan 1,3-alpha-glucosidase activity] GO:0042470 [melanosome] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	944 aa 106.9 kDa	Yes	0
GANAB-002 ENSP00000340466 ENST00000346178	Q14697 [Direct mapping] Neutral alpha-glucosidase AB Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0017177 [glucosidase II complex] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0033919 [glucan 1,3-alpha-glucosidase activity] GO:0042470 [melanosome] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	966 aa 109.4 kDa	Yes	0
GANAB-003 ENSP00000435306 ENST00000534779	E9PKU7 [Direct mapping] Neutral alpha-glucosidase AB Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005975 [carbohydrate metabolic process] GO:0030246 [carbohydrate binding] Show all	852 aa 96.5 kDa	No	0
GANAB-011 ENSP00000434805 ENST00000525994	E9PNH1 [Direct mapping] Neutral alpha-glucosidase AB Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.2 kDa	No	0
GANAB-201 ENSP00000442962 ENST00000540933	F5H6X6 [Direct mapping] Neutral alpha-glucosidase AB Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005975 [carbohydrate metabolic process] GO:0030246 [carbohydrate binding] Show all	847 aa 96.2 kDa	No	0