Cell atlas - P3H2 - The Human Protein Atlas

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P3H2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	P3H2
Gene description	Prolyl 3-hydroxylase 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HaCaT, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	P3H2 (HGNC Symbol)
Synonyms	FLJ10718, LEPREL1, MLAT4
Description	Prolyl 3-hydroxylase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	3
Cytoband	q28
Chromosome location (bp)	189956728 - 190122437
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090530 (version 83.38)
Entrez gene	55214
UniProt	Q8IVL5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVL5
Antibodypedia	P3H2 antibodies

PROTEIN BROWSER

P3H2-001	P3H2-002	P3H2-003	P3H2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P3H2-001 ENSP00000316881 ENST00000319332	Q8IVL5 [Direct mapping] Prolyl 3-hydroxylase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005604 [basement membrane] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0008285 [negative regulation of cell proliferation] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0019797 [procollagen-proline 3-dioxygenase activity] GO:0030198 [extracellular matrix organization] GO:0031418 [L-ascorbic acid binding] GO:0032963 [collagen metabolic process] GO:0055114 [oxidation-reduction process] Show all	708 aa 81 kDa	Yes	0
P3H2-002 ENSP00000408947 ENST00000427335	Q8IVL5 [Direct mapping] Prolyl 3-hydroxylase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005604 [basement membrane] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0008285 [negative regulation of cell proliferation] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0019797 [procollagen-proline 3-dioxygenase activity] GO:0030198 [extracellular matrix organization] GO:0031418 [L-ascorbic acid binding] GO:0032963 [collagen metabolic process] GO:0055114 [oxidation-reduction process] Show all	527 aa 60.4 kDa	No	0
P3H2-003 ENSP00000394326 ENST00000426003	C9JSL4 [Direct mapping] Prolyl 3-hydroxylase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 15.8 kDa	No	0
P3H2-004 ENSP00000391374 ENST00000444866	C9J313 [Direct mapping] Prolyl 3-hydroxylase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 16.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.