Expression of GNPTG in cancer - Summary

CANCER ATLAS

Gene description

N-acetylglucosamine-1-phosphate transferase, gamma subunit

Protein class

Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004055

GENE INFORMATION
Gene name	GNPTG (HGNC Symbol)
Synonyms	C16orf27, c316G12.3, CAB56184, GNPTAG
Description	N-acetylglucosamine-1-phosphate transferase, gamma subunit (HGNC Symbol)
Entrez gene summary	This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.[provided by RefSeq, Feb 2010]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1351923 - 1364113
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090581 (version 83.38)
Entrez gene	84572
UniProt	Q9UJJ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UJJ9
Antibodypedia	GNPTG antibodies

PROTEIN BROWSER

GNPTG-001	GNPTG-008	GNPTG-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNPTG-001 ENSP00000204679 ENST00000204679	Q9UJJ9 [Direct mapping] N-acetylglucosamine-1-phosphotransferase subunit gamma Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003976 [UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity] GO:0005794 [Golgi apparatus] GO:0016020 [membrane] GO:0016256 [N-glycan processing to lysosome] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0046835 [carbohydrate phosphorylation] GO:0070062 [extracellular exosome] Show all	305 aa 34 kDa	Yes	0
GNPTG-008 ENSP00000480060 ENST00000527137	A0A087WWA2 [Direct mapping] N-acetylglucosamine-1-phosphotransferase subunit gamma Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.2 kDa	Yes	0
GNPTG-009 ENSP00000435349 ENST00000529110	H0YEA7 [Direct mapping] N-acetylglucosamine-1-phosphotransferase subunit gamma Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		185 aa 20.3 kDa	Yes	0