We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Several cases of thyroid and prostate cancers displayed strong cytoplasmic positivity while a majority of liver, endometrial, renal and ovarian cancers as well as several melanomas were moderately positive. Remaining cancer cells generally displayed weak staining or were negative.
Most cancer tissues showed moderate cytoplasmic staining, with additional nuclear and membranous staining in a few cases. Few cases of endometrial cancers showed strong cytoplasmic and nuclear staining. Several cases of colorectal and ovarian cancers displayed moderate to strong cytoplasmic and membranous positivity. Several cases of gliomas, lymphomas and skin cancers were negative.
GENE INFORMATION
Gene name
MCOLN1 (HGNC Symbol)
Synonyms
ML4, MLIV, MST080, MSTP080, TRPM-L1, TRPML1
Description
Mucolipin 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009]
