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Most of the malignant cells displayed moderate nuclear positivity. A few cases of squamous cell carcinomas, lung adenocarcinomas, malignant gliomas and endometrial cancers were strongly stained. The majority of liver, stomach and urothelial cancers were weakly stained or negative.
GENE INFORMATION
Gene name
POU4F3 (HGNC Symbol)
Synonyms
BRN3C, DFNA15
Description
POU class 4 homeobox 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]