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A few cases of liver cancers exhibited moderate staining. Other malignancies were negative.
GENE INFORMATION
Gene name
SLC26A3 (HGNC Symbol)
Synonyms
CLD, DRA
Description
Solute carrier family 26 (anion exchanger), member 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]