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Cancer tissues showed weak to moderate cytoplasmic and membranous staining. A few cases of melanoma, embryonal carcinoma of testis, cholangiocarcinoma, colorectal, prostate, endometrial and renal cancers displayed strong positivity.
GENE INFORMATION
Gene name
WDR7 (HGNC Symbol)
Synonyms
KIAA0541, TRAG
Description
WD repeat domain 7 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Q9Y4E6 [Direct mapping] WD repeat-containing protein 7
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
