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IL5RA

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GENERAL INFORMATION

Gene name

 IL5RA

Gene description

 Interleukin 5 receptor, alpha

Protein class

 CD markers
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 IL5RA (HGNC Symbol)

Synonyms

 CD125, CDw125, IL5R

Description

 Interleukin 5 receptor, alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

Chromosome

 3

Cytoband

 p26.2

Chromosome location (bp)

 3066326 - 3126613

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091181 (version 83.38)

Entrez gene

 3568

UniProt

 Q01344 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01344

Antibodypedia

 IL5RA antibodies

PROTEIN BROWSER
IL5RA-001
IL5RA-002
IL5RA-003
IL5RA-004
IL5RA-005
IL5RA-006
IL5RA-007
IL5RA-008
IL5RA-009
IL5RA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL5RA-001
ENSP00000412209
ENST00000446632
Q01344 [Direct mapping]
Interleukin-5 receptor subunit alpha
A0A024R2C8 [Target identity:100%; Query identity:100%]
Interleukin 5 receptor, alpha, isoform CRA_a
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0004896 [cytokine receptor activity]
GO:0004914 [interleukin-5 receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032674 [regulation of interleukin-5 production]
GO:0038043 [interleukin-5-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0071310 [cellular response to organic substance]
Show all
 420 aa
47.7 kDa 		Yes 1
IL5RA-002
ENSP00000373358
ENST00000383846
Q01344 [Direct mapping]
Interleukin-5 receptor subunit alpha
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004914 [interleukin-5 receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0038043 [interleukin-5-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 335 aa
38 kDa 		Yes 0
IL5RA-003
ENSP00000392059
ENST00000456302
Q01344 [Direct mapping]
Interleukin-5 receptor subunit alpha
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004914 [interleukin-5 receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0038043 [interleukin-5-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 333 aa
37.7 kDa 		Yes 0
IL5RA-004
ENSP00000256452
ENST00000256452
Q01344 [Direct mapping]
Interleukin-5 receptor subunit alpha
A0A024R2C8 [Target identity:100%; Query identity:100%]
Interleukin 5 receptor, alpha, isoform CRA_a
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004914 [interleukin-5 receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0038043 [interleukin-5-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 420 aa
47.7 kDa 		Yes 1
IL5RA-005
ENSP00000309196
ENST00000311981
Q01344 [Direct mapping]
Interleukin-5 receptor subunit alpha
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004914 [interleukin-5 receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0038043 [interleukin-5-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 335 aa
38 kDa 		Yes 0
IL5RA-006
ENSP00000400400
ENST00000430514
Q01344 [Direct mapping]
Interleukin-5 receptor subunit alpha
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004914 [interleukin-5 receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0038043 [interleukin-5-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 333 aa
37.7 kDa 		Yes 0
IL5RA-007
ENSP00000390753
ENST00000438560
Q01344 [Direct mapping]
Interleukin-5 receptor subunit alpha
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004914 [interleukin-5 receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0038043 [interleukin-5-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 378 aa
42.9 kDa 		Yes 1
IL5RA-008
ENSP00000391274
ENST00000427088
C9J3K8 [Direct mapping]
Interleukin-5 receptor subunit alpha
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
 109 aa
12.3 kDa 		Yes 0
IL5RA-009
ENSP00000398117
ENST00000445701
C9J6C4 [Direct mapping]
Interleukin-5 receptor subunit alpha
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 196 aa
22 kDa 		Yes 0
IL5RA-201
ENSP00000388858
ENST00000418488
E7ERY4 [Direct mapping]
Interleukin-5 receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 325 aa
36.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.