Tissue expression of ABCC6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ABCC6
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Protein class	Cancer-related genes Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver, kidney)
GTEx:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver, kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	ABCC6 (HGNC Symbol)
Synonyms	ARA, EST349056, MLP1, MRP6, PXE, URG7
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.11
Chromosome location (bp)	16148928 - 16223522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091262 (version 83.38)
Entrez gene	368
UniProt	O95255 (UniProt - Evidence at protein level)
neXtProt	NX_O95255
Antibodypedia	ABCC6 antibodies

PROTEIN BROWSER

ABCC6-001	ABCC6-006	ABCC6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC6-001 ENSP00000205557 ENST00000205557	O95255 [Direct mapping] Multidrug resistance-associated protein 6 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007601 [visual perception] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016887 [ATPase activity] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	1503 aa 164.9 kDa	No	>9
ABCC6-006 ENSP00000461686 ENST00000575728	O95255 [Direct mapping] Multidrug resistance-associated protein 6 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007601 [visual perception] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	99 aa 10.8 kDa	No	1
ABCC6-201 ENSP00000483331 ENST00000622290	O95255 [Direct mapping] Multidrug resistance-associated protein 6 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007601 [visual perception] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016887 [ATPase activity] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	871 aa 95.9 kDa	No	>9