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RAPGEF4

CANCER ATLAS

Gene description

 Rap guanine nucleotide exchange factor (GEF) 4

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA028968
CAB004388

GENE INFORMATION

Gene name

 RAPGEF4 (HGNC Symbol)

Synonyms

 cAMP-GEFII, CGEF2

Description

 Rap guanine nucleotide exchange factor (GEF) 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 172735274 - 173052893

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091428 (version 83.38)

Entrez gene

 11069

UniProt

 Q8WZA2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WZA2

Antibodypedia

 RAPGEF4 antibodies

PROTEIN BROWSER
RAPGEF4-001
RAPGEF4-003
RAPGEF4-004
RAPGEF4-011
RAPGEF4-201
RAPGEF4-202
RAPGEF4-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAPGEF4-001
ENSP00000380271
ENST00000397081
Q8WZA2 [Direct mapping]
Rap guanine nucleotide exchange factor 4
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0017016 [Ras GTPase binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030073 [insulin secretion]
GO:0030168 [platelet activation]
GO:0030552 [cAMP binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
Show all
 1011 aa
115.5 kDa 		No 0
RAPGEF4-003
ENSP00000380274
ENST00000397085
H7BYQ0 [Direct mapping]
Rap guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030073 [insulin secretion]
GO:0030552 [cAMP binding]
GO:0043547 [positive regulation of GTPase activity]
Show all
 187 aa
22.1 kDa 		No 0
RAPGEF4-004
ENSP00000380276
ENST00000397087
Q8WZA2 [Direct mapping]
Rap guanine nucleotide exchange factor 4
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0017016 [Ras GTPase binding]
GO:0030168 [platelet activation]
GO:0030552 [cAMP binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
Show all
 867 aa
99.5 kDa 		No 0
RAPGEF4-011
ENSP00000387104
ENST00000409036
E9PB94 [Direct mapping]
Rap guanine nucleotide exchange factor 4
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030073 [insulin secretion]
GO:0030552 [cAMP binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 943 aa
107.5 kDa 		No 0
RAPGEF4-201
ENSP00000438011
ENST00000535187
B7Z278 [Direct mapping]
Rap guanine nucleotide exchange factor 4; cDNA FLJ50956, highly similar to Rap guanine nucleotide exchange factor 4; cDNA FLJ61771, highly similar to Rap guanine nucleotide exchange factor 4
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030073 [insulin secretion]
GO:0030552 [cAMP binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 791 aa
91 kDa 		No 0
RAPGEF4-202
ENSP00000440135
ENST00000538974
Q8WZA2 [Direct mapping]
Rap guanine nucleotide exchange factor 4
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0017016 [Ras GTPase binding]
GO:0030168 [platelet activation]
GO:0030552 [cAMP binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
Show all
 840 aa
96.3 kDa 		No 0
RAPGEF4-203
ENSP00000440250
ENST00000540783
Q8WZA2 [Direct mapping]
Rap guanine nucleotide exchange factor 4
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0017016 [Ras GTPase binding]
GO:0030168 [platelet activation]
GO:0030552 [cAMP binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
Show all
 858 aa
98.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.