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Moderate cytoplasmic immunoreactivity was displayed in few cases of a majority of cancers. Strong extracellular positivity was observed in all cancer tissues. Lymphomas, gliomas and head and neck, thyroid, ovarian and prostate cancers were mainly negaitve.
Distinct positivity was observed in plasma. Rare cases in several different cancer types showed weak to moderate cytoplasmic staining.
GENE INFORMATION
Gene name
TF (HGNC Symbol)
Synonyms
PRO1557, PRO2086
Description
Transferrin (HGNC Symbol)
Entrez gene summary
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]