Cell atlas - CDV3 - The Human Protein Atlas

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CDV3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Plasma membrane

Human cell
	Cytosol
	Nucleoli
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CDV3
Gene description	CDV3 homolog (mouse)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoli & plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Additional location	In addition localized to the Nucleoli (validated), Plasma membrane (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. HPA029761 , HPA029762 , HPA029763
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoli & plasma membrane.

Main location

Cytosol (validated)

Additional location

Nucleoli (validated), Plasma membrane (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA029761	A-431	Nucleoli
		Plasma membrane
		Cytosol
HPA029761	U-2 OS	Nucleoli
HPA029761	U-2 OS	Cytosol
HPA029761	U-251 MG	Nucleoli
HPA029761	U-251 MG	Cytosol
HPA029762	A-431	Plasma membrane
HPA029762	A-431	Cytosol
HPA029762	U-2 OS	Cytosol
HPA029762	U-251 MG	Cytosol
HPA029763	A-431	Cytosol
HPA029763	U-2 OS	Cytosol
HPA029763	U-251 MG	Nucleoli fibrillar center
HPA029763	U-251 MG	Cytosol

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA029762

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Cytoplasmic region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

55%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA029762	siRNA 1	U-2 OS
HPA029762	siRNA 2	U-2 OS
HPA029762	scrambled	U-2 OS

GENE INFORMATION
Gene name	CDV3 (HGNC Symbol)
Synonyms	H41
Description	CDV3 homolog (mouse) (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	133573730 - 133590261
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091527 (version 83.38)
Entrez gene	55573
UniProt	Q9UKY7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKY7
Antibodypedia	CDV3 antibodies

PROTEIN BROWSER

CDV3-001	CDV3-002	CDV3-003	CDV3-004	CDV3-005	CDV3-006	CDV3-007	CDV3-008	CDV3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDV3-001 ENSP00000264993 ENST00000264993	Q9UKY7 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008283 [cell proliferation] Show all	258 aa 27.3 kDa	No	0
CDV3-002 ENSP00000391955 ENST00000431519	Q9UKY7 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008283 [cell proliferation] Show all	213 aa 22.1 kDa	No	0
CDV3-003 ENSP00000413272 ENST00000420115	Q9UKY7 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008283 [cell proliferation] Show all	110 aa 11.9 kDa	No	0
CDV3-004 ENSP00000421340 ENST00000503932	H0Y8K3 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 20.9 kDa	No	0
CDV3-005 ENSP00000422866 ENST00000508481	D6R9V8 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	156 aa 17.3 kDa	No	0
CDV3-006 ENSP00000423349 ENST00000504867	D6R973 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 5.6 kDa	No	0
CDV3-007 ENSP00000425297 ENST00000511392	D6RDN0 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	108 aa 11.7 kDa	No	0
CDV3-008 ENSP00000421495 ENST00000515421	D6RFH2 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	108 aa 11.7 kDa	No	0
CDV3-009 ENSP00000424742 ENST00000507408	D6RAV0 [Direct mapping] Protein CDV3 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	92 aa 9.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.