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ALKBH5

GENERAL INFORMATION

Gene name

 ALKBH5

Gene description

 AlkB homolog 5, RNA demethylase

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA007196
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Esophagus
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ALKBH5 (HGNC Symbol)

Synonyms

 FLJ20308, OFOXD1

Description

 AlkB homolog 5, RNA demethylase (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 18183078 - 18209954

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091542 (version 83.38)

Entrez gene

 54890

UniProt

 Q6P6C2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P6C2

Antibodypedia

 ALKBH5 antibodies

PROTEIN BROWSER
ALKBH5-001
ALKBH5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALKBH5-001
ENSP00000382091
ENST00000399138
Q6P6C2 [Direct mapping]
RNA demethylase ALKBH5
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0007283 [spermatogenesis]
GO:0016607 [nuclear speck]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0030154 [cell differentiation]
GO:0035515 [oxidative RNA demethylase activity]
GO:0035553 [oxidative single-stranded RNA demethylation]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
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 394 aa
44.3 kDa 		Yes 0
ALKBH5-003
ENSP00000468116
ENST00000541285
K7ER58 [Direct mapping]
RNA demethylase ALKBH5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 53 aa
6.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.