Expression of CD200 in cancer - Summary

CANCER ATLAS

Gene description

CD200 molecule

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031149

GENE INFORMATION
Gene name	CD200 (HGNC Symbol)
Synonyms	MOX1, MOX2, MRC, OX-2
Description	CD200 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q13.2
Chromosome location (bp)	112332347 - 112362812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091972 (version 83.38)
Entrez gene	4345
UniProt	P41217 (UniProt - Evidence at protein level)
neXtProt	NX_P41217
Antibodypedia	CD200 antibodies

PROTEIN BROWSER

CD200-001	CD200-002	CD200-003	CD200-006	CD200-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD200-001 ENSP00000312766 ENST00000315711	P41217 [Direct mapping] OX-2 membrane glycoprotein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0042803 [protein homodimerization activity] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] Show all	269 aa 30.3 kDa	Yes	1
CD200-002 ENSP00000420298 ENST00000473539	P41217 [Direct mapping] OX-2 membrane glycoprotein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0042803 [protein homodimerization activity] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] Show all	294 aa 33 kDa	No	2
CD200-003 ENSP00000373179 ENST00000383681	F8W7G1 [Direct mapping] OX-2 membrane glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	195 aa 21.9 kDa	No	1
CD200-006 ENSP00000476114 ENST00000607597	U3KQQ2 [Direct mapping] OX-2 membrane glycoprotein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 7 kDa	Yes	0
CD200-007 ENSP00000475860 ENST00000606471	U3KQG5 [Direct mapping] OX-2 membrane glycoprotein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	202 aa 22.5 kDa	No	0