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PPP2R3C

GENERAL INFORMATION

Gene name

 PPP2R3C

Gene description

 Protein phosphatase 2, regulatory subunit B'', gamma

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA040835
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPP2R3C (HGNC Symbol)

Synonyms

 C14orf10, FLJ20644, G4-1, G5PR

Description

 Protein phosphatase 2, regulatory subunit B'', gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Chromosome

 14

Cytoband

 q13.2

Chromosome location (bp)

 35085467 - 35122517

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092020 (version 83.38)

Entrez gene

 55012

UniProt

 Q969Q6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969Q6

Antibodypedia

 PPP2R3C antibodies

PROTEIN BROWSER
PPP2R3C-001
PPP2R3C-004
PPP2R3C-008
PPP2R3C-014
PPP2R3C-015
PPP2R3C-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP2R3C-001
ENSP00000261475
ENST00000261475
Q969Q6 [Direct mapping]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001782 [B cell homeostasis]
GO:0002759 [regulation of antimicrobial humoral response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0030865 [cortical cytoskeleton organization]
GO:0032147 [activation of protein kinase activity]
GO:0043029 [T cell homeostasis]
GO:0045579 [positive regulation of B cell differentiation]
GO:0046872 [metal ion binding]
GO:0048536 [spleen development]
GO:0050864 [regulation of B cell activation]
GO:0051900 [regulation of mitochondrial depolarization]
Show all
 453 aa
53.3 kDa 		No 0
PPP2R3C-004
ENSP00000450815
ENST00000557278
A0A0C4DGK2 [Direct mapping]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001782 [B cell homeostasis]
GO:0005819 [spindle]
GO:0030865 [cortical cytoskeleton organization]
GO:0043029 [T cell homeostasis]
GO:0045579 [positive regulation of B cell differentiation]
Show all
 167 aa
20.2 kDa 		No 0
PPP2R3C-008
ENSP00000451523
ENST00000555644
Q86US5 [Direct mapping]
Chromosome 14 open reading frame transcript variant 2; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001782 [B cell homeostasis]
GO:0005819 [spindle]
GO:0030865 [cortical cytoskeleton organization]
GO:0043029 [T cell homeostasis]
GO:0045579 [positive regulation of B cell differentiation]
Show all
 190 aa
22.6 kDa 		No 0
PPP2R3C-014
ENSP00000451174
ENST00000555614
H0YJC5 [Direct mapping]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001782 [B cell homeostasis]
GO:0005819 [spindle]
GO:0030865 [cortical cytoskeleton organization]
GO:0043029 [T cell homeostasis]
GO:0045579 [positive regulation of B cell differentiation]
Show all
 226 aa
26.2 kDa 		No 0
PPP2R3C-015
ENSP00000452173
ENST00000555219
H0YJV0 [Direct mapping]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001782 [B cell homeostasis]
GO:0005819 [spindle]
GO:0030865 [cortical cytoskeleton organization]
GO:0043029 [T cell homeostasis]
GO:0045579 [positive regulation of B cell differentiation]
Show all
 128 aa
14.6 kDa 		No 0
PPP2R3C-019
ENSP00000450716
ENST00000554361
G3V2K1 [Direct mapping]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001782 [B cell homeostasis]
GO:0005819 [spindle]
GO:0030865 [cortical cytoskeleton organization]
GO:0043029 [T cell homeostasis]
GO:0045579 [positive regulation of B cell differentiation]
Show all
 226 aa
26.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.