Cell atlas - JPH4 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	JPH4
Gene description	Junctophilin 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.
RNA cell category	Group enriched (SH-SY5Y, U-2 OS, SCLC-21H)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Golgi apparatus (approved)
Mouse	Localized to the Nucleoli fibrillar center in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. CAB013492 , HPA054232
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SH-SY5Y, U-2 OS, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.

Main location

Nucleoplasm (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB013492	A-431	Nucleoplasm
CAB013492	A-431	Cytosol
CAB013492	U-2 OS	Nucleoplasm
CAB013492	U-251 MG	No staining
HPA054232	A-431	Nucleoplasm
HPA054232	A-431	Golgi apparatus
HPA054232	HeLa	Nucleoplasm
HPA054232	HeLa	Golgi apparatus
HPA054232	U-2 OS	Nucleoplasm
HPA054232	U-2 OS	Golgi apparatus

MOUSE CELLS

Main location

Nucleoli fibrillar center

Additional location

Nucleus, Golgi apparatus

Mouse gene

ENSMUSG00000022208 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA054232	NIH 3T3	Nucleus
		Nucleoli fibrillar center
		Golgi apparatus

GENE INFORMATION
Gene name	JPH4 (HGNC Symbol)
Synonyms	JPHL1, KIAA1831
Description	Junctophilin 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23568035 - 23578800
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000092051 (version 83.38)
Entrez gene	84502
UniProt	Q96JJ6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96JJ6
Antibodypedia	JPH4 antibodies

PROTEIN BROWSER

JPH4-001	JPH4-002	JPH4-004	JPH4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
JPH4-001 ENSP00000348648 ENST00000356300	Q96JJ6 [Direct mapping] Junctophilin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060402 [calcium ion transport into cytosol] Show all	628 aa 65.9 kDa	No	1
JPH4-002 ENSP00000380307 ENST00000397118	Q96JJ6 [Direct mapping] Junctophilin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005790 [smooth endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0007612 [learning] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0043198 [dendritic shaft] GO:0048167 [regulation of synaptic plasticity] GO:0050885 [neuromuscular process controlling balance] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060402 [calcium ion transport into cytosol] Show all	628 aa 65.9 kDa	No	1
JPH4-004 ENSP00000439562 ENST00000544177	F5H1L9 [Direct mapping] Junctophilin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		293 aa 30.7 kDa	No	1
JPH4-201 ENSP00000480477 ENST00000622501	A0A087WWT0 [Direct mapping] Junctophilin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		629 aa 66.1 kDa	No	1