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RNF31

GENERAL INFORMATION

Gene name

 RNF31

Gene description

 Ring finger protein 31

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA048745 , CAB009063
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RNF31 (HGNC Symbol)

Synonyms

 FLJ10111, FLJ23501, HOIP, ZIBRA

Description

 Ring finger protein 31 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 24146683 - 24160661

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092098 (version 83.38)

Entrez gene

 55072

UniProt

 Q96EP0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96EP0

Antibodypedia

 RNF31 antibodies

PROTEIN BROWSER
«
RNF31-001
RNF31-004
RNF31-005
RNF31-007
RNF31-010
RNF31-011
RNF31-014
RNF31-015
RNF31-019
RNF31-021
RNF31-026
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF31-001
ENSP00000315112
ENST00000324103
Q96EP0 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016874 [ligase activity]
GO:0023035 [CD40 signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035631 [CD40 receptor complex]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0071797 [LUBAC complex]
GO:0097039 [protein linear polyubiquitination]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 1072 aa
119.7 kDa 		No 0
RNF31-004
ENSP00000453574
ENST00000559275
Q96EP0 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016874 [ligase activity]
GO:0023035 [CD40 signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035631 [CD40 receptor complex]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0071797 [LUBAC complex]
GO:0097039 [protein linear polyubiquitination]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 921 aa
102.5 kDa 		No 0
RNF31-005
ENSP00000452972
ENST00000560787
H0YKX0 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0071797 [LUBAC complex]
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 917 aa
102.3 kDa 		No 0
RNF31-007
ENSP00000454032
ENST00000560875
H0YNJ0 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 56 aa
6.2 kDa 		No 0
RNF31-010
ENSP00000454048
ENST00000559533
H0YNK5 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0071797 [LUBAC complex]
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 149 aa
15.5 kDa 		No 0
RNF31-011
ENSP00000453423
ENST00000557991
H0YM13 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0071797 [LUBAC complex]
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 170 aa
19.3 kDa 		No 0
RNF31-014
ENSP00000453948
ENST00000560071
H0YNC1 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0071797 [LUBAC complex]
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 61 aa
6.3 kDa 		No 0
RNF31-015
ENSP00000453645
ENST00000559260
H0YMK6 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 32 aa
3.3 kDa 		No 0
RNF31-019
ENSP00000453501
ENST00000560754
H0YM83 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0046872 [metal ion binding]
GO:0071797 [LUBAC complex]
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 136 aa
16 kDa 		No 0
RNF31-021
ENSP00000452820
ENST00000559719
H0YKI4 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0071797 [LUBAC complex]
Show all
 165 aa
18.2 kDa 		No 0
RNF31-026
ENSP00000453471
ENST00000559308
H0YM57 [Direct mapping]
E3 ubiquitin-protein ligase RNF31
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 53 aa
5.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.