Cell atlas - TOX4 - The Human Protein Atlas

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TOX4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus
	Vesicles

Human cell
	Nucleoli
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	TOX4
Gene description	TOX high mobility group box family member 4
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Nucleoli (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA017880 , HPA027551
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli & vesicles.

Main location

Nucleus (approved)

Additional location

Nucleoli (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA017880	A-431	Nucleoplasm
HPA017880	U-2 OS	Nucleoplasm
HPA017880	U-251 MG	Nucleoplasm
HPA027551	A-431	Nucleoplasm
HPA027551	A-431	Vesicles
HPA027551	U-2 OS	Nucleus
		Nucleoli
		Vesicles
HPA027551	U-251 MG	Nucleus
		Nucleoli
		Vesicles

GENE INFORMATION
Gene name	TOX4 (HGNC Symbol)
Synonyms	C14orf92, KIAA0737, LCP1
Description	TOX high mobility group box family member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	21476597 - 21499175
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000092203 (version 83.38)
Entrez gene	9878
UniProt	O94842 (UniProt - Evidence at protein level)
neXtProt	NX_O94842
Antibodypedia	TOX4 antibodies

PROTEIN BROWSER

TOX4-001	TOX4-005	TOX4-011	TOX4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TOX4-001 ENSP00000477868 ENST00000613569	O94842 [Direct mapping] TOX high mobility group box family member 4 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0072357 [PTW/PP1 phosphatase complex] Show all	621 aa 66.2 kDa	No	0
TOX4-005 ENSP00000406196 ENST00000457430	C9J919 [Direct mapping] TOX high mobility group box family member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	170 aa 17.8 kDa	No	0
TOX4-011 ENSP00000402195 ENST00000416256	C9JNL1 [Direct mapping] TOX high mobility group box family member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	222 aa 23.5 kDa	No	0
TOX4-201 ENSP00000393080 ENST00000448790	O94842 [Direct mapping] TOX high mobility group box family member 4 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0072357 [PTW/PP1 phosphatase complex] Show all	621 aa 66.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.