Expression of TGM1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Transglutaminase 1

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Cervical cancer

STAINING SUMMARY

HPA040171	CAB015159

GENE INFORMATION
Gene name	TGM1 (HGNC Symbol)
Synonyms	ICR2, LI, LI1, TGASE, TGK
Description	Transglutaminase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24249114 - 24264432
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000092295 (version 83.38)
Entrez gene	7051
UniProt	P22735 (UniProt - Evidence at protein level)
neXtProt	NX_P22735
Antibodypedia	TGM1 antibodies

PROTEIN BROWSER

TGM1-001	TGM1-002	TGM1-004	TGM1-005	TGM1-006	TGM1-007	TGM1-008	TGM1-009	TGM1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TGM1-001 ENSP00000206765 ENST00000206765	P22735 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001533 [cornified envelope] GO:0003810 [protein-glutamine gamma-glutamyltransferase activity] GO:0005515 [protein binding] GO:0006464 [cellular protein modification process] GO:0018149 [peptide cross-linking] GO:0030216 [keratinocyte differentiation] GO:0031224 [intrinsic component of membrane] GO:0031424 [keratinization] GO:0043163 [cell envelope organization] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	817 aa 89.8 kDa	No	0
TGM1-002 ENSP00000439446 ENST00000544573	P22735 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001533 [cornified envelope] GO:0003810 [protein-glutamine gamma-glutamyltransferase activity] GO:0005515 [protein binding] GO:0006464 [cellular protein modification process] GO:0018149 [peptide cross-linking] GO:0030216 [keratinocyte differentiation] GO:0031224 [intrinsic component of membrane] GO:0031424 [keratinization] GO:0043163 [cell envelope organization] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	375 aa 40.6 kDa	No	0
TGM1-004 ENSP00000452690 ENST00000561067	A0A0G2JL93 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1 kDa	No	0
TGM1-005 ENSP00000452822 ENST00000560443	H0YKI6 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7 kDa	No	0
TGM1-006 ENSP00000453234 ENST00000560478	H0YLJ6 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.4 kDa	No	0
TGM1-007 ENSP00000454070 ENST00000560226	H0YNM4 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 4.5 kDa	No	0
TGM1-008 ENSP00000453840 ENST00000558074	H0YN27 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 14.5 kDa	No	0
TGM1-009 ENSP00000453337 ENST00000559136	H0YLT9 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0018149 [peptide cross-linking] Show all	209 aa 23.4 kDa	No	0
TGM1-010 ENSP00000453701 ENST00000559669	H0YMQ8 [Direct mapping] Protein-glutamine gamma-glutamyltransferase K Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003810 [protein-glutamine gamma-glutamyltransferase activity] GO:0018149 [peptide cross-linking] Show all	128 aa 14 kDa	No	0