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DAZL

GENERAL INFORMATION

Gene name

 DAZL

Gene description

 Deleted in azoospermia-like

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in seminiferous ducts.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA019593 , HPA019777 , HPA047113
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 DAZL (HGNC Symbol)

Synonyms

 DAZH, DAZL1, DAZLA, MGC26406, SPGYLA

Description

 Deleted in azoospermia-like (HGNC Symbol)

Entrez gene summary

 The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 3

Cytoband

 p24.3

Chromosome location (bp)

 16586792 - 16670306

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092345 (version 83.38)

Entrez gene

 1618

UniProt

 Q92904 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92904

Antibodypedia

 DAZL antibodies

PROTEIN BROWSER
DAZL-001
DAZL-002
DAZL-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAZL-001
ENSP00000382373
ENST00000399444
Q92904 [Direct mapping]
Deleted in azoospermia-like
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0007281 [germ cell development]
GO:0007283 [spermatogenesis]
GO:0008494 [translation activator activity]
GO:0045948 [positive regulation of translational initiation]
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 295 aa
33.2 kDa 		No 0
DAZL-002
ENSP00000250863
ENST00000250863
Q92904 [Direct mapping]
Deleted in azoospermia-like
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001556 [oocyte maturation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005844 [polysome]
GO:0007147 [female meiosis II]
GO:0007275 [multicellular organismal development]
GO:0007281 [germ cell development]
GO:0007283 [spermatogenesis]
GO:0008494 [translation activator activity]
GO:0042802 [identical protein binding]
GO:0045836 [positive regulation of meiotic nuclear division]
GO:0045948 [positive regulation of translational initiation]
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 315 aa
35.2 kDa 		No 0
DAZL-004
ENSP00000398109
ENST00000454457
E7EV40 [Direct mapping]
Deleted in azoospermia-like
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 204 aa
22.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.