Cell atlas - TRPM7 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TRPM7

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	TRPM7
Gene description	Transient receptor potential cation channel, subfamily M, member 7
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA052173
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA052173	A-431	Nucleoplasm
	HPA052173	U-2 OS	Nucleoplasm
	HPA052173	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	TRPM7 (HGNC Symbol)
Synonyms	CHAK1, LTRPC7, TRP-PLIK
Description	Transient receptor potential cation channel, subfamily M, member 7 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	50552473 - 50686815
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000092439 (version 83.38)
Entrez gene	54822
UniProt	Q96QT4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96QT4
Antibodypedia	TRPM7 antibodies

PROTEIN BROWSER

TRPM7-001	TRPM7-002	TRPM7-004	TRPM7-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPM7-001 ENSP00000320239 ENST00000313478	Q96QT4 [Direct mapping] Transient receptor potential cation channel subfamily M member 7 A0A024R5V1 [Target identity:100%; Query identity:100%] Transient receptor potential cation channel, subfamily M, member 7, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0003779 [actin binding] GO:0004674 [protein serine/threonine kinase activity] GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0010961 [cellular magnesium ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016340 [calcium-dependent cell-matrix adhesion] GO:0017022 [myosin binding] GO:0031032 [actomyosin structure organization] GO:0034220 [ion transmembrane transport] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070266 [necroptotic process] GO:0070588 [calcium ion transmembrane transport] Show all	1865 aa 212.7 kDa	No	6
TRPM7-002 ENSP00000453277 ENST00000560955	H0YLN8 [Direct mapping] Transient receptor potential cation channel subfamily M member 7; Transient receptor potential cation channel, subfamily M, member 7, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005216 [ion channel activity] GO:0005524 [ATP binding] GO:0005623 [cell] GO:0006468 [protein phosphorylation] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0010961 [cellular magnesium ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	1864 aa 212.6 kDa	No	6
TRPM7-004 ENSP00000452873 ENST00000560638	A0A0C4DGL2 [Direct mapping] Transient receptor potential cation channel subfamily M member 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005623 [cell] GO:0006468 [protein phosphorylation] GO:0006812 [cation transport] GO:0010961 [cellular magnesium ion homeostasis] GO:0016021 [integral component of membrane] Show all	535 aa 62.7 kDa	No	5
TRPM7-010 ENSP00000454066 ENST00000561267	H0YNM0 [Direct mapping] Transient receptor potential cation channel subfamily M member 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005623 [cell] GO:0006468 [protein phosphorylation] GO:0006812 [cation transport] GO:0010961 [cellular magnesium ion homeostasis] GO:0016021 [integral component of membrane] Show all	234 aa 26.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.